One-dimensional (1-D) ice flow models are used to construct the age scales at the Dome C and Dome Fuji drilling sites (East Antarctica).The poorly constrained glaciological parameters at each site are recovered by fitting independent age markers identified within each core.We reconstruct past accumulation rates, that are larger than those modelled
Objective functions used as performance metrics for hydrological models: state-of-the-art and critical analysis
ABSTRACT Hydrological models (HMs) can be applied for different purposes, and a key step is model calibration using objective functions (OF) to quantify the agreement between Wild Yam observed and calculated discharges.Fully understanding the OF is important to properly take advantage of model calibration and interpret the results.This study evalua
A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium
The cranial endo and dermal skeletons, which comprise PLL 2G11 the vertebrate skull, evolved independently over 470 million years ago and form separately during embryogenesis.In mammals, much of the cartilaginous chondrocranium is transient, undergoing endochondral ossification or disappearing, so its role in skull morphogenesis is not well studied
Impact of the deep convection of isoprene and other reactive trace species on radicals and ozone in the upper troposphere
Observations of a comprehensive suite of inorganic and organic trace gases, including non-methane hydrocarbons (NMHCs), halogenated organics and oxygenated volatile organic compounds (OVOCs), obtained from the NASA DC-8 over Canada during the ARCTAS aircraft campaign in July 2008 illustrate that convection is important for redistributing both long-
Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: a protocol for a cohort study from Scotland and Wales
Abstract Background Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms.An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is unclear.There are particular concerns that HRT could accelerate cancer progression in women with ca